Nicotinamide Adenine Dinucleotide (NAD+) is a critical coenzyme found in every living cell. It plays a fundamental role in metabolism, acting as an electron carrier in redox reactions. However, in the context of aging and longevity research, NAD+ has taken center stage.

## The Decline of NAD+

Studies show that as organisms age, NAD+ levels naturally decline. This depletion is linked to mitochondrial dysfunction, metabolic disorders, and cellular senescence. Replenishing NAD+ in laboratory models has become a primary strategy for studying age reversal.

## Sirtuin Activation

NAD+ is the essential fuel for sirtuins (SIRT1 through SIRT7). Sirtuins are a family of signaling proteins involved in regulating cellular health, DNA repair, and inflammation. Without adequate NAD+, sirtuins cannot function. In research, supplying NAD+ is shown to activate sirtuins, promoting DNA repair and extending cellular lifespan.

## DNA Repair (PARPs)

Poly (ADP-ribose) polymerases (PARPs) are enzymes that repair damaged DNA. They also require NAD+ to function. By providing high-purity NAD+ in vitro, researchers can study the direct impact of coenzyme availability on genomic stability and cellular resilience.

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*Disclaimer: All products are strictly for in vitro laboratory research use only.*