In endocrinology research, Growth Hormone Secretagogues (GHS) are compounds that stimulate the secretion of Growth Hormone (GH) from the pituitary gland. Unlike synthetic HGH, secretagogues signal the body's own models to produce GH, preserving the natural pulsatile release.

## The GHRP Family

Growth Hormone Releasing Peptides (GHRPs) are synthetic compounds that act as ghrelin receptor agonists.
- **GHRP-6:** The first of its class, heavily studied for its potent GH-releasing capabilities. However, research shows it also strongly stimulates ghrelin, which can increase appetite in models.
- **GHRP-2:** A second-generation peptide that is more potent than GHRP-6 at releasing GH, but with a slightly less pronounced effect on ghrelin and appetite signaling.

## Ipamorelin: The Selective Secretagogue

Ipamorelin represents a major leap in peptide research. It is a highly selective GHRP. In laboratory studies, Ipamorelin has been shown to stimulate GH release with the same potency as GHRP-6, but it does not significantly elevate cortisol, prolactin, or appetite-inducing ghrelin. This makes it the preferred compound for researchers seeking a clean, targeted GH response without off-target side effects.

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*Disclaimer: All compounds are supplied strictly for in vitro laboratory research.*